Not trying to be smart here, Bill.. I doubt it.
Look around and you'll see what I mean:
W 2.0 Is "The" way to go
SEO does the trick.
Craigslist will swamp you with buyers
Use Ebay to increase your sales
And so on, and so on, and so on.
I honestly don't believe there's a "Next Big Thing". Some things work well for one person, and not the next.
Try it all, and make your own decission.
Pete