Hi Gregg,

Many will recommend Quark as being the Best...
And is usually every Printers preference of software
to work with...
http://www.quark.com/
http://www.quark.com/products/xpress/

But here are a couple Excellent resources with all kinds of information on a Multiple of related topics that can Help Learn a thing or two.

http://desktoppub.about.com/od/designprojects/
http://www.allgraphicdesign.com/

Phil