Michael, from someone who has been through the fire, here is my absolute guaranteed solution.
Back up Acronis Will do everything you want it to do.
Anti-virus Pc-Cillin from Trend Micro
Been using them for around 5 years. Reliable and (so far) never a problem.
Has a built in firewall.
I'm pretty anal about viruses after the nasty attack a long time ago.
Pc-Cillin is real time protection. Mine is set to check for updates every couple hours. I do a full scan of my hard drive twice a week automatically.
That said, I also manually use Adaware SE from Lavasoft, Spybot S&D, SuperAntiSpyware as well as . These are all free and I only run these every week or two.
I've gone through about 5 backup programs and Acronis is the best I've tried. Worst? Norton Ghost.